Steven L Chang, Michael L Chang, Alyssa L Chang, Brian L Chang and Lawrence D Chang
Cutaneous squamous cell carcinoma (SCC) is the second-most common skin cancer and can present with a wide variety of skin lesions. Nodular types have been described and are often characterized by hyperkeratinization, ulceration, and increased vascularity. This case study presents an elderly gentleman with a history of skin cancer who presented with a subcutaneous nodule with no overlying skin changes and was later diagnosed with SCC confined to the dermis without an epidermal origin. We present this case with the hope of increasing awareness of the wide variety of presentations of SCC and, in particular, subcutaneous forms of SCC, as these may be more dangerous and require more aggressive treatment.