Rajeev Sati1*, Shivali Sagar1, Monika Bisht2
Holmskioldia sanguinea is a Sub-Himalayan plant that has been cultivated in the Americas, Europe, Indo-China, Asia-Pacific, and Southern Africa. The present study seeks to evaluate the methanolic leaf extract of Holmskioldia Sanguinea (MLEHS) for its anti-diabetic effect against streptozotocin–nicotinamide induced type 2 diabetic models in albino wistar rats. Phytochemical screening, oral glucose tolerance test and acute toxicity study were carried out. Graded doses of MLEHS (100mg/kg, 200mg/kg and 400mg/kg) were administered to diabetic rats for 21 days. The activity was evaluated by using some biochemical parameters such as blood glucose levels, serum lipid profiles, liver profile markers (AST, ALP, ALT), renal profile markers (serum creatinine, blood urea). Type 2 diabetes significantly altered these parameters, while oral administration of the MLEHS significantly ameliorated them.