Yuan Yao, Jinjun Wang, Bin Liu, Xuan Zhang and Stanley M Naguwa
Multicentric Reticulohistiocytosis (MRH) is a rare histiocytic disorder that primarily involves the skin and joints but can affect multiple visceral organs. A female patient presented a characteristic papulonodular skin eruption and polyarthritis with positive Antinuclear Antibody (ANA), and skin biopsy findings demonstrated classic features of MRH. The patient’s clinical manifestations were in remission after treatment, yet X-ray showed progressive erosions of finger joints. MRH is an aggressive, debilitating and disabling condition, an optimal treatment strategy is necessary performed to improve outcome.