Norbert O Temajo
The Co-operative Specificity Theory explains the reciprocal recognition between specific MHC DR/DQ molecules in a haplotype resulting in a co-operation that precipitates susceptibility to T1D. Co-operativity between protein molecules is the probable formation of one H-bond which seduces the formation of a greater number of H-bonds leading to a strong association between the two molecules. In co-operative specificity the binding between positively and negatively charged aa residues on the specific DR- and DQ-molecules occurs in a procedure that is rapid, exact and in an all-or-none fashion resulting in only one achieved maximal extremum. We theorize that protein molecules in the proteome sense each other’s level of entropy ΔS in search of partner parity, with lowest ΔS existing between two molecules spelling co-operativity with resulting expansion of ΔS.